Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner
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چکیده
منابع مشابه
Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner
Neural stem and progenitor cell (NSPC) fate is strongly influenced by mechanotransduction as modulation of substrate stiffness affects lineage choice. Other types of mechanical stimuli, such as stretch (tensile strain), occur during CNS development and trauma, but their consequences for NSPC differentiation have not been reported. We delivered a 10% static equibiaxial stretch to NSPCs and exami...
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Stem cell differentiation is regulated by a variety of cues including growth factors and extracellular matrix (ECM), although the role that the ECM has in this process is less understood. Here we provide examples of how the composition, concentration, and elastic modulus of matrix as well as its temporal and spatial location plays a key role in regulating cell fate. Natural variation of matrix ...
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Yi Wen1,2, Sijun Hu3, Junjie Wu1,2* 1State Key Laboratory of Military Stomatology, Xi'an, Shaanxi Province, People's Republic of China 2Department of Orthodontics, Fourth Military Medical University, School of Stomatology, Xi'an, Shaanxi Province, People's Republic of China 3State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University,...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep08499